PIEZO2 in sensory neurons and urothelial cells coordinates urination
نویسندگان
چکیده
منابع مشابه
Piezo2-mediated mechanotransduction in peripheral sensory neurons
23 Piezo2 ion channels are critical determinants of the sense of light touch in vertebrates. Yet, their 24 regulation is only incompletely understood. We recently identified myotubularin related protein-2 25 (Mtmr2), a phosphoinositide (PI) phosphatase, in the native Piezo2 interactome of murine dorsal 26 root ganglia (DRG). Here, we demonstrate that Mtmr2 attenuates Piezo2-mediated rapidly ada...
متن کاملSensory Biology: It Takes Piezo2 to Tango
A trio of papers has resolved an outstanding controversy regarding the function of Merkel cells and their afferent nerve fiber partners. Merkel cells sense mechanical stimuli (through Piezo2), fire action potentials, and are sufficient to activate downstream sensory neurons.
متن کاملCross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development.
Temporal and spatial coordination of multiple cell fate decisions is essential for proper organogenesis. Here, we define gene interactions that transform the neurogenic epithelium of the developing inner ear into specialized mechanosensory receptors. By Cre-loxP fate mapping, we show that vestibular sensory hair cells derive from a previously neurogenic region of the inner ear. The related bHLH...
متن کاملPIEZO2 as the anomalous mechanotransducer channel in auditory hair cells
Throughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anomalous mechanosensitive (MS) channels on the top surface of the cells. The anomalous MS channels are responsible for the reverse-pola...
متن کامل[Morphological transformation of sensory ganglion neurons and satellite cells].
Sensory ganglion neurons in higher vertebrates are unique in that they are pseudounipolar with a single stem process that divides at some distance from the cell body into central and peripheral processes. In the early stages of development, these neurons are bipolar but later they became pseudounipolar. This developmental process of sensory ganglion neurons with satellite cells was examined by ...
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ژورنال
عنوان ژورنال: Nature
سال: 2020
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-020-2830-7